Skanderup lab

@ Genome Institute of Singapore


Interested in Data Science and Precision Oncology? Postdoc and Data Scientist positions open (February 2020)

Research


Computational Precision Oncology
We develop and apply computational approaches to study how anti-cancer drugs work in patients. We study how tumors become resistant to treatments, and how to use machine learning approaches to predict the optimal treatment for each patient. To accomplish this, we work closely with excellent clinical research groups in Singapore and abroad.

Cancer Liquid Biopsy
Profiling of circulating tumor DNA (ctDNA) in blood offers a non-invasive approach to detect cancer and monitor disease progression. By profiling ctDNA over time, we study how tumors respond to treatments and build predictive models for clinical decision support. We are building a national-scale database of cancer liquid biopsy samples.

Tumor Systems Biology
Signaling between cancer and non-malignant cells of the tumor microenvironment is critical in many aspects of tumor progression. However, there is a lack of approaches to study this phenomenon at scale in tumors. We are developing integrated experimental and computational techniques to study tumors at a systems level.

Research highlights


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Integrative cancer genomics
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Non-coding mutations in cancer
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Discovery of miRNA-target interactions in cancer

Methods & online resources

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OncoSG - Cancer Genomics Data Portal
src.gisapps.org/OncoSG/
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Access cancer genomics data in R
CGDSR
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Discover miRNA targets in cancer
CancerMiner
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cWords - Motif discovery from expression data
version 1.0 version 2.0 (web)

People



Yu Amanda Guo (PostDoc)
PhD in bioinformatics and genetics from Cornell University, USA.

Umesh Ghoshdastider (PostDoc)
PhD in biochemistry and bioinformatics from Goethe University, Germany.

Neha Rohatgi (PostDoc)
PhD in systems biology, University of Iceland.

Guanhua Peter Zhu (PostDoc)
PhD in computational biology, Nanyang Technological University, Singapore.

Mei Mei Chang (Bioinformatics Scientist)
Bachelor in biostatistics from National University of Singapore.

Kiran Krishnamachari (Bioinformatics Scientist)
Bachelor in engineering, National University of Singapore.

Weitai Huang (Graduate student)
A*STAR/NUS graduate student.

Marjan Mojtabavi Naeini (Graduate student)
A*STAR ARAP fellow.

Anders Jacobsen Skanderup (Principal Investigator)
PI at GIS and Adjunct Assistant Professor at School of Computing, National University of Singapore. PhD in bioinformatics from University of Copenhagen, Denmark, and previously a Postdoc at Memorial Sloan-Kettering Cancer Center, USA.

Current interns
- Dylan Lu, University of British Columbia
- Alexander Swift-Scott, University of British Columbia

Past lab members and interns
Hamzeh Mesrian, University of Isfahan; Egor Revkov, Moscow Institute of Physics and Technology; Anuar Yeraliyev, University of British Columbia; Kayla Lee, University of British Columbia; Satwik Bhattamishra, Birla ITS; Tanmay Kulshrestha, Birla ITS; Karthik MuthuKumar, Northeastern University, Boston; Tin Nguyen, University of Science, HCM City; Sundar Solai, Harvard University; Probhonjon Baruah, Indian Institute of Technology, Guwahati

Publications


Selected publications

See Google Scholar for a complete list of publications.